Senior Scientist, Mass Spectrometry

<h3>Accountabilities</h3><li>Design and execute mass spectrometry-based studies to investigate biological questions, support emerging therapeutic modalities, and advance drug discovery programs.</li><li>Develop, optimize, and implement mass spectrometry-based screening, proteomics, and analytical workflows for compound discovery, target identification, target engagement, mechanism-of-action studies, and pathway biology.</li><li>Evaluate and introduce new mass spectrometry technologies, analytical methods, and workflows to expand research capabilities and improve experimental performance.</li><li>Operate, maintain, troubleshoot, and continuously optimize LC-MS instrumentation and related analytical platforms to ensure reliable performance and high-quality data.</li><li>Analyze and interpret complex mass spectrometry datasets, translating experimental findings into meaningful biological insights and actionable recommendations for drug discovery.</li><li>Develop and refine sample preparation, chromatographic separation, and analytical methods for diverse biological applications.</li><li>Collaborate with multidisciplinary teams across biology, chemistry, and related scientific fields to design fit-for-purpose analytical strategies and support research objectives.</li><li>Contribute original scientific ideas, challenge existing assumptions, and help advance innovative research projects through iterative experimentation and creative problem-solving.</li><li>Maintain accurate experimental records and documentation while staying current with developments in mass spectrometry, proteomics, and analytical technologies.</li><li>Coordinate with external contract research organization (CRO) partners when required and provide technical or project leadership within cross-functional teams.</li><h2>Requirements</h2><li>
<strong>Education and experience:</strong>Ph.D. in Analytical Chemistry, Biochemistry, Biology, Chemistry, Pharmaceutical Sciences, or a related discipline, with at least 2 years of relevant experience; alternatively, an M.S. with at least 4 years or a B.S. with at least 5 years of relevant industry, academic, or postdoctoral experience. A Ph.D. is strongly preferred.</li><li>
<strong>Mass spectrometry expertise:</strong>Strong foundational knowledge of mass spectrometry, with hands-on experience operating, troubleshooting, and optimizing liquid chromatography–mass spectrometry (LC-MS) instrumentation.</li><li>
<strong>Analytical method development:</strong>Demonstrated experience developing, implementing, and optimizing mass spectrometry-based analytical methods, screening assays, and/or proteomics workflows.</li><li>
<strong>Drug discovery applications:</strong>Proven ability to apply mass spectrometry techniques to biological research and drug discovery, including target identification, target engagement, protein characterization, interaction analysis, or pathway interrogation.</li><li>
<strong>Quantitative proteomics:</strong>Experience with quantitative proteomics and other mass spectrometry-based approaches for protein identification, characterization, and biological pathway analysis.</li><li>
<strong>Instrumentation:</strong>Experience with Orbitrap mass spectrometry systems, particularly Astral platforms, and/or Agilent quadrupole time-of-flight (Q-TOF) instruments is preferred.</li><li>
<strong>Specialized workflows:</strong>Familiarity with affinity selection mass spectrometry (ASMS) and affinity purification mass spectrometry (AP-MS) is desirable, particularly in drug discovery settings.</li><li>
<strong>Data analysis and computational skills:</strong>Proficiency with mass spectrometry data acquisition, processing, and analysis software, including tools for complex quantitative datasets, MS-based screening, and assay development.</li><li>
<strong>Scientific problem-solving:</strong>Strong analytical thinking, troubleshooting capabilities, and creativity in developing solutions to challenging scientific and technical problems.</li><li>
<strong>Biological knowledge:</strong>Knowledge of cancer biology and relevant signaling pathways is an advantage.</li><li>
<strong>Communication and collaboration:</strong>Excellent written, verbal, and presentation skills, with the ability to communicate complex scientific findings clearly and work effectively across multidisciplinary teams.</li><li>
<strong>Leadership and adaptability:</strong>Demonstrated initiative, a collaborative mindset, a commitment to continuous learning, and the ability to contribute to project coordination or provide matrix leadership when needed.</li><li>
<strong>Work arrangement:</strong>Ability to work on-site in San Carlos, California, as required by the original posting. The role is advertised with San Carlos and Remote (US) location options; candidates should confirm the applicable work arrangement during the hiring process.</li><h2>Benefits</h2><li>
<strong>Competitive compensation:</strong>Annual base salary ranging from<strong>$150,200 to $187,800</strong>, depending on qualifications, relevant experience, skills, and work location.</li><li>
<strong>Performance incentives:</strong>Eligibility for an annual bonus plan for non-commercial roles.</li><li>
<strong>Equity opportunities:</strong>Potential discretionary equity awards and the option to participate in an employee stock purchase plan.</li><li>
<strong>Healthcare coverage:</strong>Comprehensive medical, dental, and vision insurance.</li><li>
<strong>Retirement and financial benefits:</strong>401(k) retirement plan, flexible spending accounts (FSA), and health savings accounts (HSA), where applicable.</li><li>
<strong>Insurance protection:</strong>Life insurance coverage.</li><li>
<strong>Work-life balance:</strong>Paid time off and wellness benefits.</li><li>
<strong>Scientific development:</strong>Opportunities to explore emerging analytical technologies, contribute to innovative research programs, and collaborate with experts across scientific disciplines.</li><li>
<strong>Meaningful impact:</strong>The opportunity to contribute to therapeutic innovation and research aimed at advancing cancer treatment.</li>